We've seen: http://www.mini-itx.com/projects/wraithse/
And many of us (myself for sure) really didn't like the extreme level of, uh, whatever-ness that went into it.
Today I just Googled up the Mini-ITX SE/86! Nicely done in general, but the rear port setup leaves a little to be desired. The CD-ROM cutout is nice, for sure. Not a slot-load, but to get a tray loader in there, it's good.